Therapy for idiopathic precocious puberty in children

Article information

J Korean Med Assoc. 2011;54(9):953-956

Publication date (electronic) : 2011 September 15

doi : https://doi.org/10.5124/jkma.2011.54.9.953

Kye Shik Shim, MD ¹, Jung Tae Kim, PhD ²

¹Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.

²Department of Pharmacy, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Pharmacy, Seoul, Korea.

Corresponding author: Kye Shik Shim, 64sks@khnmc.or.kr

Received 2011 June 27; Accepted 2011 July 10.

Abstract

The incidence of idiopathic precocious puberty is rapidly increasing in Korea. The most common medication used for treatment is a gonadotropin releasing hormone agonist. However, there is some debate regarding the indication and timing of treatment, and the dosage of the medication, because there are many factors that can affect growth in children after delaying puberty. Also, there are new medications that can potentially delay the puberty with children, for example, gonadotropin releasing hormone antagonists and aromatase inhibitors which require extensive further study.

Keywords: Precocious puberty; Gonadotropin-releasing hormone; Agonist

References

1. Rosenfield RL, Cooke DW, Radovick S. In : Sperling MA, ed. Puberty and its disorders in the female. Pediatric endocrinology 2008. 3rd edth ed. Philadelphia: Saunders Co; 530–609.

2. Styne D, Grumbach M. In : Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Puberty: ontogeny, neuroendocri-nology, physiology, and disorders. Williams textbook of endocrinology 2008. 11th edth ed. Philadelphia: Saunders Co; 969–1166.

3. The early detection of precocious puberty [Internet] 2011. cited 2011 Aug 10. Seoul: Health Insurance Review & Assessment Service; Available from: http://www.hira.or.kr/cms/rc/rce_news/1205871_10816.html.

4. Shim KS, Bae CW, Yang YJ. A comparative study of the pu-berty suppression effect of gonadotropin-releasing hormone agonist in precocious or early puberty girls. Korean J Pediatr 2008. 51634–639.

5. Jin HY, Choi JH, Yoo HW. Evaluation of efficacy of GnRH agonist on predicted adult height (PAH) in patients with central precocious puberty using two different dosages. J Korean Soc Pediatr Endocrinol 2010. 15120–125.

Article information Continued

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Figure 1

The total number and medical cost of patients with precocious puberty from 2006 through 2010 in Korea (From The early detection of precocious puberty [Internet]. Seoul: Health Insurance Review & Assessment Service; 2011) [3].